Anatol J Cardiol. 2024 Jan;28(1):44-54. doi: 10.14744/AnatolJCardiol.2023.3463. Alberto Cresti 1, Pasquale Baratta 1, Francesco De Sensi 1, Elio Aloia 1, Bruno Sposato 2, Ugo Limbruno 1 Abstract Background: Large-scale multicentric studies reported that, despite advances in diagnosis, antibiotics, and surgical treatment, infective endocarditi....
Triple Therapy in COPD in Real Life: Is It Better to Use Single or Multiple Inhalers?
J Clin Med. 2024 Oct 17;13(20):6191. doi: 10.3390/jcm13206191. Bruno Sposato 1, Alberto Ricci 2, Leonardo Gianluca Lacerenza 3, Elisa Petrucci 3, Alberto Cresti 4, Pasquale Baratta 4, Antonio Perrella 1, Andrea Serafini 5, Marco Scalese 6 Abstract Background: Today, single-inhaler ICS/LAMA/LABA (SITT) COPD therapies are available. It is unclear whe....
Prognostic Value of Response to Inhaled Nitric Oxide Administration in Patients with Acute Respiratory Distress Syndrome Related to Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Indian Journal of Respiratory Care (2024): 10.5005/jp-journals-11010-1134 Pasquale Baratta , Francesco De Sensi , Alberto Cresti , Bruno Sposato , Rosa Buontempo , Genni Spargi , Ugo Limbruno. Ab s t r ac t Background: The role of inhaled nitric oxide (iNO) in managing acute respiratory distress syndrome COVID-19 related (C-ARDS) is debatable. The ....
Pre-biologic FeNO might predict anti-IL-5/IL-5Rα response to treatment in severe asthmatics
J Asthma. 2025 Jan 17:1-6. doi: 10.1080/02770903.2025.2451691. Online ahead of print. Bruno Sposato 1, Marco Scalese 2, Gianna Camiciottoli 3, Giovanna Elisiana Carpagnano 4, Corrado Pelaia 5, Pierachille Santus 6, Girolamo Pelaia 7, Paolo Cameli 8, Elena Bargagli 8, Leonardo Gianluca Lacerenza 9, Dejan Radovanovic 6 10, Paola Rogliani 11, Mauro Ma....
Clinical Asthma Remission Obtained with Biologics in Real Life: Patients' Prevalence and Characteristics
Background: The prevalence of clinical asthma remission with biologics in severe asthma has not been well understood yet. We do not even know whether there might be characteristics that identify subjects prone to remission of the disease. Materials and methods: Retrospectively, four groups of severe asthmatics already treated with Omalizumab,....
COVID-19 severity appears to be reduced in spring/summer
Background: because of different human behaviours, SARS-CoV-2 spread may be lower in spring/summer. On the contrary, it is not clearly known whether the clinical course/severity of hospitalized patients infected by SARS-CoV-2 can be different in the various seasons.. Objectives: to understand whether there were differences in severity of COVI....
Influence of allergic status and nasal polyposis on long-term Benralizumab response in eosinophilic severe asthma
Objective: It is unclear whether Benralizumab effectiveness in severe eosinophilic asthma can be influenced by nasal polyposis (NP) or allergic status associations. We evaluated whether Benralizumab long-term efficacy in asthma outcomes could be different in subjects with atopy (SAEA) compared to the effectiveness in those without allergies (SNAEA)....
COVID-19 severity appears to be reduced in spring/summer
Background: because of different human behaviours, SARS-CoV-2 spread may be lower in spring/summer. On the contrary, it is not clearly known whether the clinical course/severity of hospitalized patients infected by SARS-CoV-2 can be different in the various seasons.. Objectives: to understand whether there were differences in severity of COVID-19 i....
Influence of allergic status and nasal polyposis on long-term Benralizumab response in eosinophilic severe asthma
Objective: It is unclear whether Benralizumab effectiveness in severe eosinophilic asthma can be influenced by nasal polyposis (NP) or allergic status associations. We evaluated whether Benralizumab long-term efficacy in asthma outcomes could be different in subjects with atopy (SAEA) compared to the effectiveness in those without allergies (SNAEA)....
B4GALT1 as a New Biomarker of Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a disease characterized by progressive scarring of the lung that involves the pulmonary interstitium. The disease may rapidly progress, leading to respiratory failure, and the long-term survival is poor. There are no accurate biomarkers available so far. Our aim was to evaluate the expression of the B4GALT1 in....
Severe asthma and long-term Benralizumab effectiveness in real-life
Objective: Long-term efficacy of Benralizumab in real life is not clearly known. We assessed the long-term effectiveness persistence to anti-IL-5R treatment in a group of severe eosinophilic asthmatics. Patients and methods: We retrospectively analyzed 95 individuals affected by severe asthma (36 males ̶ 37.9%; mean age 58.1 ± 12.2) treated w....
Longitudinal assessment of systemic steroid therapy on hyperinflammatory endothelial biomarker profiles and serology responses of COVID-19 patients
Keywords: COVID-19; CXCL9; Cytokine; Dexamethasone; Inflammation; Serology. Conflict of interest statement Jonathan T. Sims, Venkatesh Krishnan, Ching-Yun Chang, Josh Poorbaugh, Montanea Daniels, Stephanie L. Beasley, Lin Zhang, & George H. Rodgers are employees and may be shareholders of Eli Lilly and Company. Fabio Lena, Leonardo G. Lacerenza....
